Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter-chromosomal movement
Hundreds of genes interact with the yeast nuclear pore complex (NPC), localizing at the nuclear periphery and clustering with co-regulated genes.Dynamic tracking of peripheral genes shows that they cycle on Sensor EXT Wire and off the NPC and that interaction with the NPC slows their sub-diffusive movement.Furthermore, NPC-dependent inter-chromosom